To filter blood or universal leukoreduction: what is the answer?
نویسنده
چکیده
The safety of the blood supply has been a concern over the past 20-30 years because of the transmission of infectious diseases. Blood is still routinely tested for viruses, and leukoreduction is an effective strategy to reduce the transmission of cell-associated viruses. Clinically, the benefits of leukoreduction include decreases in transfusion reactions, HLA alloimmunization, infections, fever episodes, and antibiotic use. Although leukoreduction will add cost to a unit of blood, projections indicate that leukoreduced blood will become the standard of care.
منابع مشابه
Evaluation of Leukoreduction in Packed Cell Units Filtered by Home-Made Bedside Filters: Pre and Post Revision of Product Technology and Materials According to Standard Values
Introduction: Leukocytes causing a wide variety of side effects after transfusion are present in all blood products prepared by standard methods. As a consequence, the use of filter technology for leukoreduction has been widely practiced .According to AABB accreditation in 1996, leukoreduced blood components must contain less than 5×106 leukocytes per unit, but sometimes this value is higher ev...
متن کاملIs there justification for universal leukoreduction?
The Associação Brasileira de Hematologia, Hemoterapia e Terapia Celular (ABHH), the institution that represents the Associação Médica Brasileira (AMB) in respect to hematology, transfusion therapy and cell therapy in Brazil hereby states: Prospective randomized studies have not demonstrated any positive clinical impact with the universal use of blood components in which the initial number of le...
متن کاملUniversal leukoreduction of cellular blood components in 2001? No.
Leukocytes are known to have a number of biologic effects associated with allogeneic blood transfusion ❚Table 1❚. The potential clinical importance of these effects, which are the focus of current debate over the merits of “universal” leukocyte reduction (leukoreduction; cellular components with <5 × 106 leukocytes) include the following: febrile-associated transfusion reactions (FATRs), transf...
متن کاملEffects of leukocyte depletion filters on matrix metalloproteinase activation in an extracorporeal circulation circuit.
Matrix metalloproteinases (MMPs) are a family of endopeptidases that function to remodel tissue during both normal physiology and pathology. Research performed by the Medical University of South Carolina found an increased release of several MMP species during cardiopulmonary bypass (CPB), including the subtype MMP-9, but whether and to what degree the extracorporeal circulation circuit (ECC) i...
متن کاملAn association between decreased cardiopulmonary complications (TRALI and TACO) and implementation of universal leukoreduction of blood transfusions
Background—Cardiopulmonary adverse events after transfusion include acute lung injury (TRALI) and circulatory overload (TACO), which are potentially lethal and incompletely understood. Study Design and Methods—To determine whether the incidence of TRALI and TACO was affected by leukoreduction we conducted a retrospective, before and after study of acute transfusion reactions for the seven years...
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عنوان ژورنال:
دوره 8 شماره
صفحات -
تاریخ انتشار 2004